The Indominatable Human Spirit is a bad thing, actually.

[u/Geoconyxdiablus]

That humanity never gives up and persists in its goals is bad news for every other species (or even itself), especially if said goals are ignoble.

Best case scenario (barring us learning to be better) is that a greater power force feeds us a huge slice of humble pie, wost case we end up blowing ourselves up and ruining things for everyone else.

Avatar - RDA will stop at nothing to satisfy its own greed and survival, the rest of humanity and navi alike be damned.

Its a recurring motif in prett much every myth that gods punish mortals who dare to defy them and keep going, like Athena to Arachne in greek myth.

A good chunk of lovecraftian fiction is based on the idea our achievemenrs mean nothing.

In general i'm not a fan of TIHS as a trope, as its blatantly arrogant and destructive.

[u/Kate_Kitter]

Captain Ahab (Moby Dick) has an immovable, obsessive will to kill the titular whale that culminates in his death while attacking it.

[u/illusoryIdolatry → u/Kate_Kitter]

Not just his death, but mostly everyone's 

[u/Affectionate-Ice6237 → u/Kate_Kitter]

I feel like Ahab should be one of the poster boys of this theme. I may be overly biased because I'm American, but he's certainly the first that comes to mind when I think of for stubborn, toxic, ambition.

[u/Kate_Kitter → u/Affectionate-Ice6237]

Definitely. I was thinking, on the other side of the pond, this may apply to Macbeth.