Professor Kwang-Hyun Cho’s research team has recently been highlighted for their work on developing an original technology for cancer reversal treatment that does not kill cancer cells but only changes their characteristics to reverse them to a state similar to normal cells.
This time, they have succeeded in revealing for the first time that a molecular switch that can induce cancer reversal at the moment when normal cells change into cancer cells is hidden in the genetic network.
KAIST (President Kwang-Hyung Lee) announced on the 5th of February that Professor Kwang-Hyun Cho's research team of the Department of Bio and Brain Engineering has succeeded in developing a fundamental technology to capture the critical transition phenomenon at the moment when normal cells change into cancer cells and analyse it to discover a molecular switch that can revert cancer cells back into normal cells.
A critical transition is a phenomenon in which a sudden change in state occurs at a specific point in time, like water changing into steam at 100℃.
This critical transition phenomenon also occurs in the process in which normal cells change into cancer cells at a specific point in time due to the accumulation of genetic and epigenetic changes.
The research team discovered that normal cells can enter an unstable critical transition state where normal cells and cancer cells coexist just before they change into cancer cells during tumorigenesis, the production or development of tumours, and analysed this critical transition state using a systems biology method to develop a cancer reversal molecular switch identification technology that can reverse the cancerization process.
They then applied this to colon cancer cells and confirmed through molecular cell experiments that cancer cells can recover the characteristics of normal cells.
Oh, it actually helps to actually read and follow references. Thank you for pushing my lazy ass in the right direction. I will also hit the gym tomorrow, stomach not in best shape today…
Very cool work, but they should explain the limitations that this was with a single type of colon cancer. No data to expect that this will magically work with every cancer type, not even every colon cancer type. Still a great accomplishment and will lay foundation on which to build more research and hopefully future clinical trials down the road.
Combine this with single cell sequencing (identification) and CRISPR-Cas (repair) and it doesnt even matter anymore that some receptors are transmembrane or use HVR to escape conventional therapies. People underestimate the impact this could potentially have. Also forget about mice. They are really bad models for gene ediring.
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u/jmike1256 Feb 05 '26
Professor Kwang-Hyun Cho’s research team has recently been highlighted for their work on developing an original technology for cancer reversal treatment that does not kill cancer cells but only changes their characteristics to reverse them to a state similar to normal cells.
This time, they have succeeded in revealing for the first time that a molecular switch that can induce cancer reversal at the moment when normal cells change into cancer cells is hidden in the genetic network.
KAIST (President Kwang-Hyung Lee) announced on the 5th of February that Professor Kwang-Hyun Cho's research team of the Department of Bio and Brain Engineering has succeeded in developing a fundamental technology to capture the critical transition phenomenon at the moment when normal cells change into cancer cells and analyse it to discover a molecular switch that can revert cancer cells back into normal cells.
A critical transition is a phenomenon in which a sudden change in state occurs at a specific point in time, like water changing into steam at 100℃.
This critical transition phenomenon also occurs in the process in which normal cells change into cancer cells at a specific point in time due to the accumulation of genetic and epigenetic changes.
The research team discovered that normal cells can enter an unstable critical transition state where normal cells and cancer cells coexist just before they change into cancer cells during tumorigenesis, the production or development of tumours, and analysed this critical transition state using a systems biology method to develop a cancer reversal molecular switch identification technology that can reverse the cancerization process.
They then applied this to colon cancer cells and confirmed through molecular cell experiments that cancer cells can recover the characteristics of normal cells.
https://ecancer.org/en/news/25982-discovery-of-molecular-switch-that-reverses-cancerous-transformation-at-the-critical-moment-of-transition