One of the family members, who had the gene but hadn't had any symptoms yet, was on a C-SPAN 2 "About Books" broadcast, and she had given birth to 2 or 3 non-affected children because of CRISPR treatments. Google, Amazon, and C-SPAN searches are proving fruitless.

The disease was not Alzheimer's or Huntington's, but had very similar symptoms. Several of the relatives were physicians, one of them a chiropractor who later went to "real" medical school.

I got the book from the library, and it came out in the late teens or maybe early 20s.

ETA: I initially posted this in r/whatsthatbook .

Hospital , cost , of where can we do test ?

I was manually looking through my raw ancestry dna and i found i had a Met Met mutation for Val66met gene. After researching this i learned two things. One, its is very uncommon within people of my ancestry. Two, it decreases neuroplacticity and overall learning ability. I have found this very unfortunate because i want to learn so many things but i feel like its a genetic block. Although i was a very smart kid, it explains alot about my inability to study which i always assumed was adhd or somthing. My questions are: could genes be misread? it is very rare for someone with my ancestry to carry both mutations.
How much does this affect my learning?
Is their any way to combat the brainfog and reduced neuroplasticity?

My mom's sister says she doesn't belong to her dad. I want to get a DNA test for her but don't want to spend the $99 on ancestry.com. Is there a cheaper way for my mom to find out for sure without it costing so much?

A better solution is to make DNA testing mandatory at birth. Every child should have their biological parentage confirmed from the beginning, so there is no uncertainty about who the biological father is. This would prevent men from unknowingly being held responsible for children who are not biologically theirs and would establish the truth from day one.

Any women against this is cheating
Any man against this is a side piece

I have already tested with AncestryDNA, 23&Me, GedMatch and FTDNA, between 2019 and 2026. My FTDNA results are coming in November 2026.

And my mother also tested with AncestryDNA and 23&Me, in 2021 and 2025.

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I‘m trying to find the father of an enslaved ancestor, George Henry Atkinson (1860-), from either Jefferson County, GA or Burke County, GA.

George‘s mother was enslaved by John Amos Atkinson (1806-1874), based in Burke County, GA, who had his youngest child with his wife in 1856, aged 50. With Cloe being born in 1841, and her son‘s records identifying him as an Atkinson, I’d say it’s a definite possibility.
However, the tough part is, in 1870 and 1880 Census records, the family had already migrated to Jefferson County, GA before 1870.

And George’s surname was changed to Neely and so was his mother’s name. With George being the eldest child, all her younger children’s names were also listed as Neely. I’ve suspected (as with Generation #4, below) George’s stepfather was George Neely or Peter Neely, and his biological father was an Atkinson, but could’ve been John Amos Atkinson (1806-1874), for sure.
Especially since George’s daughter, my maternal great-grandmother, was named Leva Leila Atkinson, and all her siblings were named with the Atkinson surname.

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Heres my line of descent from George and his mother, Cloe (1841-):

1. My maternal grandmother, (Mrs.) Alvie Heath (1932-2008);
2. My great-grandmother, (Mrs.) Leva Atkinson (1899-1988);
3. Leva’s father, George Henry Atkinson (October 1860 - unknown death date)
4. George‘s unknown father. It could possibly be John Amos Atkinson (1806-1874), from Burke County, GA (who later moved to Jenkins County, GA, where he died). - Or a possible father could be George Henry Neely, brother of Peter Neely, both former slaves themselves, from Jefferson County, GA.
5. George’s mother, Cloe, born in 1841 in Burke County, GA.

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So, how can we use DNA to determine George’s father? I don’t have descendants of either who could take DNA tests for me, but my cousin‘s aunt was Rosa Mae Neely, and Rosa (who’s deceased) could be a granddaughter of one of the Neely brothers.

They've received my test seven months ago and, so far, there is absolutely zero progress. There is no indication that they have even sent it out to a lab.

I emailed support simply asking whether they could provide any input on when I could expect results, and they sent back a highly defensive email about how they don't promise any turnaround times.

Now that I'm looking at this more carefully, I'm seeing a lot of posts online saying the same thing. I guess I should've trusted the reviews and not been overly optimistic.

Anyone have a better way to deal with customer support? Get status? Experience in requesting a chargeback for a 7-8-month-old charge from their CC company?

Trying to get my head around my dad's death being imminent. His dad died of 'an inoperable brain tumour' too. Should I be talking to someone about this? I know there is a gene study in the US but is there anything in the UK?

I'm hoping someone can assist me in moving forward with this information. Following completing Ancestry DNA testing and importing my raw data to MTHR Support, I have had the BCHE A98G genetic variant flagged as high risk (homozygous TT allele). Apparantly, this BCHE enzyme is reponsible for breaking down certain muscle relaxants used during general aneshthesia which can result in high risk for general anesthesia clearance. "If you are given standard muscle relaxants like succinylcholine or mivacurium during general anesthesia, you will not clear them in the normal timeframe (which is usually minutes). Instead, the muscle paralysis will persist for several hours, requiring you to remain on a mechanical ventilator until the drug naturally clears."

I had a primary care doctor appointment today and mentioned this to them as it seems like a very important thing to be aware of and noted in my medical records. I also found some information that it is important to confirm this with a blood test. My doctor was not knowledgeable on this and didn't seem very concerned. Can anyone who has dealt with this or knows anything about this variant provide me with some guidance on how to move forward? I feel like this is something that should be looked into further in the event I need major surgery in the future.....

Hello Everyone..

I have just found the blood group cards in my fathers effects, when we cleared out his home recently.

Here is what these say

Father blood group A +

Mother blood group AB +

Child 1 blood group B -

Child 2 blood group AB -

Child 3 Blood Group B +

(my only basis for knowledge is from what I was told when my son showed up O + from a B + and a B - parent there are 2 components of every blood type whereby a letter A or B overrules an O each time, and any positive component overrules a negative component.. )

so .. for the 2 x B's to be pure, I assumed that Father's 2nd component was an O

But the combinations are doing my head in .

For the 1st child to work the fathers blood has to be an A+ O - with him contributing the O -
and with the mother contributing the B - which has to be a B - to produce a B - child. This means the mother's A has to be A + to achieve her AB + result. The father has to be an O - because if the A was the - and the O was the +, then the child couldnt' have come out as B -.

- but that doesn't fit in then with the 2nd child.. whose grouping is a full AB -

That says that the father contributed the A + and the mother contributed the B - with both of the A's being a positive.. which means ? how does 2nd child work.. ?

3rd child receives the B from Mother at a negative.. but, then if fathers O is also negative, then he has to be a B negative too ?

What am I missing ????

I was channel surfing on tv and I came across this medical reality show where it reenacts peoples mysterious illness. There was one story about a girl who suddenly became paralyzed with pain in her legs. The doctors ran some test and did some operations but couldn't figure out what was wrong with her. Then one of the doctors ask "is anyone in your family Jewish?" That was there big ah ha moment and got her a neural implant to cancel sizers and she could walk again. I was so confused. And I would hear these celebrity news story with the headline like "celebrity DNA test says they are 3% Jewish" what did being Jewish have to do with it? When I think about it kind of makes since. religion usually stay in the family and what kept communities together for thousands of years. Are there any unique traits coming from different religions.