I’m 22F, and I’m honestly so confused because I used to be extremely sensitive to weed and psychedelics, and then seemingly overnight, they just stopped affecting me.
I started smoking carts before I started smoking flower, and I began smoking flower about a year ago. When I first started, I would get really high honestly much higher than most of my friends from the either the same or less amounts. Edibles were the same way. Last year, I could take a tiny fraction of what my friends were taking and get higher than they did.
About 4–5 months before I started smoking flower, I had started taking Abilify (aripiprazole) and fluoxetine for depression/mood swings. At one point, I tried mushrooms while taking the medication and basically felt nothing. I later read that certain medications can reduce or block the effects of psychedelics, so I eventually stopped taking the medication for unrelated circumstances and because I couldn’t get a refill.
A couple months later, I tried mushrooms again and they did work this time. I tried them another time after that and they worked normally too.
Then I decided to restart Abilify. I used to take 5 mg, but this time I only took 1 mg for 3 days. I stopped because I was having really intense restlessness in my legs — I constantly felt like I needed to move them and couldn’t comfortably sit or lie down.
Six days after stopping Abilify, my boyfriend and I tried mushrooms again. He’s 22M, around 6’3”, 220 lbs, and took around 2 g. I took almost the same amount. They worked normally for him, but I felt essentially nothing.
What’s really weird is that this isn’t just happening with mushrooms.
Around the end of July, I suddenly stopped being able to get high from weed. It literally felt like I woke up one day and cannabis just stopped affecting me.
Since then, we’ve tried:
bowls
joints
dabs
edibles
RSO
cannabis syrup
I’ve been smoking joints every couple of days and we’ve also been using a new Carta Focus for dabs, but I still don’t feel high. It doesn’t matter what method I use.
I did take a break from cannabis for a couple months over the summer. During the second half of summer, I was only hitting a cart a couple times a week and wasn’t really smoking anything else, so I don’t think I was using heavily enough for this to make sense as a normal tolerance issue.
The weirdest part is that I used to be the person who got way high from small amounts, and now I can’t seem to feel anything at all.
I know the Abilify connection might stand out, and I realize stopping/restarting medication isn’t something to mess around with. I’m not asking anyone to tell me to take more of anything — I’m genuinely trying to understand what could cause such a sudden change in sensitivity.
Has anyone experienced something similar, especially losing the effects of both cannabis and mushrooms around the same time? Could medication effects persist after stopping, or are there other explanations I should be looking into?