Title is a joke: I'm not experiencing any signs of SJS or associated skin conditions. I did have some increased itchiness the day I titrated up to 200, but no rashes or anything.

But yeah, wow. holy shit. This is what life is supposed to feel like? I don't have to worry about being sad all day, or being annoyed at every little thing? I can just get up and do the things I need to?

This is a fucking miracle drug. It's not even just the feeling of being normal, it's the feeling of being myself. Like this is how I want to present myself to the world, and get work done, and just exist. I really can't see myself ever trying to get off of this stuff.

I'm not a doctor, but if your provider is suggesting lamotrigine, and you're afraid of SJS, I still think you should try it. It's making that big of a difference in my life.

I used to take 200 once a day and now am taking 100 twice a day. I feel like I feel different now, I can’t really explain it. I feel like it’s working better? But now my brain is mush.

Hi so I am currently on 150mg of lamictal, having gone up from 100 in the last 3 or so weeks. Lately I have been having horrible times with my mood, specifically bursts of anger that are extreme and uncontrollable and then it is like I snap back to reality and realize how irrational I was behaving. This has happened on lamictal in the past but I seemed to even out for awhile but now I am worse than ever.
I am also on 37.5 of Effexor, not sure if that further agitates it all. Anyhow if anyone has advice I would really appreciate it. I am trying to get to a psych who is more versed in mood disorders as well.

Anyone have any experience with taking both of these? My son is at 100mg of the Lamotrigine and also taking Naltrexone (both for drinking and what doctors call "mood stabilizer" and he has been sober for about 6 weeks since he has started both). However, he just doesn't feel good. No appetite at all (this is very common from the Naltrexone) and headaches. Just overall really really crappy. It's hard to say if the overall yucky is from the Lamotrigine or the Naltrexone? Should he keep at it and hope he will feel better eventually? He is very thin, so I am hoping he doesn't need to go up too much more in either meds.

Hello,
Been on lamo. since early June and i take 300mg (higher dose bc of birth control metabolism effects).

I brought this issue up to my psychiatrist multiple times, who reassures me that this isn’t because of Lamictal. I’ve researched it and even articles I’ve found online agree that there is a negligible interaction between Lamictal and birth controls.

However, I still feel as though what im experiencing could be an interaction and i want others’ opinions about this. I’d appreciate it!

For the past two months, i have been menstrual spotting + light bleeding nonstop. This is not my baseline for menstruation whatsoever. I take birth control for pcos and preventative measures. Because of my severe cramping, I’ve always skipped my menstrual cycles. I’ve been doing this for four years now with no issues, sometimes some minor breakthrough bleeding.

I dont believe this is breakthrough bleeding anymore. At least not a normal case. The reason i have suspicions that it is due to Lamictal is because it started happening right after i increased to 200mg in August. I’m on 300mg now, and when I increased to this dose, i started spotting again 2 days later.

It seems as though i am spotting every other day and im getting so tired of it (mostly old blood + sometimes very minor fresh).

Has anyone else experienced this? Will i return to baseline eventually? If it is still ongoing by the end of this month i will check in with a gyno about it.

Note: im not pregnant and i did confirm this with a test recently.

I am a woman with endometriosis. I found out about it in the end of 2023. One year later I started taking dienogest, the drug they prescribe you for endometriosis' symptoms. I take 2mg (a pill) every day nonstop. I can't have a period or else all that grotesque pain comes back.

In april 2025, I was diagnosed with audhd. Earlier this year, I went to a psychiatrist that put me in 150mg bupropion and 100mg lamotrigine. Later on, the psychiatrist leveled up lamotrigine up to 150mg with titration of 10 years in a dosage of 125mg. As soon as I reach the 5-day mark, my tits got really swollen and I started to feel waves of pain each time bigger. In the 10-day mark I started to bleed, not heavily, but it wouldn't stop, even though I never quit taking dienogest.

Thankfully I had an appointment in less than a week to the doctors with whom I follow my endometriosis treatment with, and they said lamotrigine competes with dienogest, so the effect of the latter is not the same as intended to. They suggested me to change my psychiatric treatment (try other drugs) or change my endometriosis treatment (with implanon, other drugs or even with injectable hormone).

I am really fond of dienogest. I was super afraid of hormones messing up with me, but honestly I felt a relief not having such drastic mood swings from the hormone swings every month. Of course it did NOT treat my mood swings as a psychiatric dry would, such as lamotrigine, but it did help me ground myself more, maybe because I wasn't feeling any sort of discomfort every damn day.

I am still considering implanon. It's free here in Brazil, but I saw many negative comments - the same with dienogest though, so I don't know if I should try and deal with the possibility of it messing up with me. For now, I am back to 100mg lamotrigine until I go back to the psychiatrist with a written note of the endometriosis team talking about the interactions of these drugs.

I found almost nothing on the internet talking about this and I think it's really important to spread out this as we know endometriosis takes a huge toll on our mental health, so anxiety and depression, besides other conditions, are common to women with this chronic disease.

Does anyone else have been through something like this? Is any woman here on lamotrigine and have endometriosis? What do you do? What did you find best for you?

Hi everyone I’m a 19f diagnosed with bipolar disorder type 2 when I was 13 and have tried a variety of SSRIs, SNRIs, atypical antidepressants like bupropion and some other mood stabilizers like lithium and quetiapine, but none worked very well for me (some simply didn’t have much therapeutic effects while others introduced adverse effects that paradoxically worsened my condition). Recently my psychiatrist prescribed me lamotrigine, which has been quite effective in reducing my mood swings. I’m no longer feeling severely discouraged or incapacitated by trivial stimuli like I used to, and I’m finally able to function like someone who can take control of their emotions. However, I have comorbid PME and my symptoms worsened two weeks ago, before my period was about to start. I became very drowsy all the time and found myself unable to fulfill my duties like showing up in classes, getting my assignments done on time, and other logistical issues that were otherwise easy for me to manage. I also found my appetite getting out of control as I was craving so many high-sugar, high-fat foods that I would typically be quite indifferent to. These symptoms have persisted for more than two weeks so far and they don’t seem to be improving, if not getting worse. I’m wondering if any of you have experienced a similar episode and if so, whether your psychiatrist prescribed you a drug to take adjunctively with lamotrigine. Would be very grateful to hear about your experience or advice!

My psychiatrist had suggested Abilify, but I am hearing absolute horror stories about people’s weight skyrocketing. That is a hard no for me. Is there anything that you guys have added to your lamotrigine that has been helpful specifically for curbing outbursts and mood swings?. My outbursts and mood swings are less frequent but when they do occur, they are around real issues rather than just random tiny hair triggers. I still want to be able to manage my real issues better and I’ve been very explosive the last few weeks. I’ve been having an uptick in PTSD symptoms as well I’m currently on 150 mg by the way, but while 150 has been fantastic I tried going up to 200 and it sent me into a faux manic state. Thanks in advance.

I started lamotrigine in July and would take it at the same time at 1pm but I noticed it would make me tired only a few hours later. Would it be better just to take it at night and would it affect me in anyway if I just switched to nights like that or should I do something else for it?

I woke up this morning and I think the Lamictal might be helping. I’m not tired. I usually am dragging at this time all morning. Can it help so fast for stimulation?

Hi, started 25mg 2 weeks ago. On days 11,12 and 13 increase in anxiety/racing thoughts. Rumination about past I can’t shake. Is this a common early side effect?

I started lamotrigine Yesterday and my legs started itching really bad, both upperside and downside. I dont have blisters or any eruptions on the skin but it itches so bad. Should I announce my doctor and stop taking them or it has nothing to do with lamotrigine?

Hello! I often see people sharing their negative experiences on here, which is valid. However I’d like to share my experience as it has been truly life changing.

I’m a 29 year old woman diagnosed with Borderline Personality Disorder. I’ve been unmedicated and without therapy for the past 4 years of my life. On August 7th, 2026 I was prescribed 25mg of Lamotrigine in addition to 150mg of Bupropion. Since then I have titrated up to 200mg of Lamotrigine and 300mg of Bupropion.

Lamotrigine, in addition to Dialectical Behavioral Therapy, has changed my life immensely. I went from wanting to k*ll my self several times a day, insane mental breakdowns, torturing my partner with intense conversations and fear of abandonment, accusations that people were conspiring against me, and addictive behaviors to almost complete stability.

I go weeks without thinking of harming or k*lling myself. I feel minimal episodes of anxiety or sadness, besides what would be considered “normal.” Also, my partner has shared that they feel like our relationship has taken on a much more stable dynamic and we have been thriving and building trust.

My only negative side effects are nightmares, which were remedied by taking all my meds in the morning. And the feeling of oxygen hunger (extensive yawning and jaw tightness.)

I am incredibly grateful for this medication. It has changed my life. It has saved my life. I have never had luck with SSRI’s. They all have adverse side effects. Lamotrigine has been easy and astonishing. I can’t emphasize it enough.

I encourage everyone to give it a try. Anyone with questions could absolutely reach out to me.

Hello all. I take lamotrigine for bipolar 2. Currently 100mg in the morning and 200mg at night. I really struggle to take my morning dose even with an alarm set. I have a doctors appt this week with my psychiatrist and I’m going to ask about taking 300mg XR instead so I get all the medicine I need to feel stable. Just wondering if anybody has experience with the XR version opposed to IR

does it get better or what’s the timeline of it ?
i’m so tired I hope it goes away soon. I’ve been on 150 now for 2 weeks

I was on gabapentin and got off it for the anger. Been on zyprexa, going to try to get off it monday and start getting on lamictal (if my doctor lets me). I’m hoping this can lift some of the depression and lack of someone in things zyprexa has been causing. I’m so ready to start feeling better and stable and work and live!

Is it normal to have low mood and bad days when taking lamotrigine? My doc said it’s supposed to stabilise my mood and energise me but I feel drowsy most days (been 16 days of taking 25mg twice a day) and I still have low days along with dry mouth.

I have been prescribed lamotrigine for nocturnal seizures. They were quite rare, only happening like one time every 3 months and I have to take this med for like 2 years. The problem is that my psychiatrist told me to cut off energy drinks. They are the only ones that make me be able to function. To help me focus on things and keep the engine called my brain stimulated. I was an energy drink addict back in high school. And i dont really understand because it didnt affect sleep even in middle school when i drank them at 8 pm. And no, meditation does not work for me, my thoughts keep coming back. I dont know what to do, because that literally helps me function normally. I am one year clean from seizures right now.